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Subject: yeast infection 

   
   J Parasitol 2001 Apr;87(2):457-60
   
Effect of iron on the virulence of Trichomonas vaginalis.

    Ryu JS, Choi HK, Min DY, Ha SE, Ahn MH
    
   Department of Parasitology, Hanyang University College of Medicine,
   Seoul, Korea.
   
   The role of iron was evaluated with respect to the virulence of
   Trichomonas vaginalis in mice. Iron-supplemented and iron-depleted
   Diamond's trypticase-yeast extract-maltose (TYM) media were prepared
   by adding 360 microM of ferrous sulfate and 100 microM of
   2,2'-dipyridyl. Trophozoites cultivated from normal TYM and
   iron-supplemented TYM media produced subcutaneous abscesses; however,
   trichomonads grown in an iron-deficient TYM medium failed to produce
   any pathology. In addition to the increased virulence of trophozoites
   in mice, iron affects the level of adherence and the cytotoxicity of
   trichomonads to HeLa cells, which are significantly reduced in
   trophozoites grown in iron-deficient medium. In conclusion, it is
   suggested that under iron-depleted conditions such as that induced by
   2,2'-dipyridyl the virulence of T. vaginalis is reduced.
   
   PMID: 11318588, UI: 21215643
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