(HOME) Subject: iron/stills

   
   Sangyo Ika Daigaku Zasshi 2000 Jun 1;22(2):189-200
   
[Hyperferritinemia and diseases].

   [Article in Japanese]
   
    Ota T
    
   Department of Central Clinical Laboratory, University Hospital,
   University of Occupational and Environmental Health, Kitakyushu,
   Japan.
   
   [Medline record in process]
   
   Ferritin is the principal iron storage protein participating in iron
   metabolism. As serum ferritin levels often reflect the amount of
   storage iron in the body, physicians have measured serum ferritin in
   order to evaluate iron deficiency or overload. Although a rise in
   serum ferritin concentration occurs in iron overload,
   hyperferritinemia without it has been reported in some inflammatry
   diseases and malignancies. Some cytokines have been reported to be
   responsible for the elevation of ferritin production. Studies on serum
   isoferritin in adult Still's disease and other diseases, especially
   measurements of the proportion of glycosylated ferritin, have been
   widely accepted. Pathophysiological properties of the increased serum
   ferritin are not clear. However, we should be aware that the
   hyperferritinemia is not a result, but is profoundly participating in
   the disease process.
   
   PMID: 10862414, UI: 20319768
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