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Subject: iron/schizophrenia/chorea

   
   Schizophr Res 1995 Jul;16(1):73-6
   
Sydenham's chorea and schizophrenia: a case report.

    Casanova MF, Crapanzano KA, Mannheim G, Kruesi M
    
   Medical College of Georgia, Augusta 30910, USA.
   
   The following is a case report of a patient with Sydenham's chorea who
   later developed schizophrenia. Autopsy examination of this patient
   revealed mineral deposits in the basal ganglia. The deposition of
   minerals, especially iron, within subcortical brain structures has
   been associated with dopaminergic abnormalities, schizophreniform
   symptoms, and abnormal movement disorders. The psychosis these
   patients experience is sometimes resistant to treatment with
   traditional neuroleptics. A CT or MRI scan may prove useful in
   screening those patients with Sydenham's chorea that develop psychotic
   symptoms.
   
   PMID: 7547648, UI: 96015587
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