Subject: B 6/pyridoxal/dialysis

   
   Adv Perit Dial 2000;16:308-12
   
Vitamin B6 deficiency in elderly patients on chronic peritoneal dialysis.

    Moriwaki K, Kanno Y, Nakamoto H, Okada H, Suzuki H
    
   Department of Nephrology, Saitama Medical School, Japan.
   
   [Medline record in process]
   
   Polyneuropathy is one of the most frequent manifestations in chronic
   uremia. Among the factors related to polyneuropathy, vitamin B6
   deficiency is well known. The exact prevalence of vitamin B6
   deficiency related to neurological manifestations has not been
   previously reported. We studied vitamin B6 status, collected
   self-reported symptoms, and carried out full neurological examinations
   in 66 patients on chronic peritoneal dialysis. Vitamin B6 status was
   estimated by direct measurement of pyridoxal phosphate. In general,
   symptoms related to vitamin B6 deficiency are peripheral neuropathies,
   such as paresthesia, burning and painful dysesthesias, and thermal
   sensations. These symptoms were reported and assigned one of five
   grade scores. Of our 66 patients, 12 patients complained at least one
   sensory abnormality. The levels of vitamin B6 in the patients varied
   between 1.0 ng/mL and 30 ng/mL. Patients who complained of
   neurological symptoms owing to vitamin B6 deficiency were
   significantly older than the other patients. In analyzing the
   symptomatic cases before and after vitamin B6 supplementation, a
   significant correlation was seen between the level of vitamin B6 and
   symptoms. Within one month after initiation of oral vitamin B6
   supplementations (30 mg daily), levels of pyridoxal phosphate rose,
   and sensory abnormalities improved in 8 of 12 patients. When
   peripheral neuropathy is suspected in elderly patients on chronic
   peritoneal dialysis, vitamin B6 deficiency should be taken into
   consideration as the cause. If vitamin B6 deficiency is appropriately
   treated by oral supplementation, sensory abnormalities can be
   eliminated.
   
   PMID: 11045317, UI: 20500078
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