Subject: chelator/iron/bacteria

   
   Antimicrob Agents Chemother 1996 May;40(5):1298-1300
   
Trophozoite elimination in a rat model of Pneumocystis carinii pneumonia by
clinically achievable plasma deferoxamine concentrations.

    Merali S, Chin K, Grady RW, Clarkson AB Jr
    
   Department of Medical and Molecular Parasitology, New York University
   School of Medicine, New York 10016, USA.
   
   In a rat model of Pneumocystis carinii pneumonia, a 3-week infusion of
   deferoxamine producing concentrations in plasma of > or = 1.5
   micrograms m-1 eliminated the trophozoite life cycle stage. Since this
   concentration is well below that routinely achieved in patients
   treated for iron overload, deferoxamine has promise as a therapy for
   AIDS-associated P.carinii pneumonia.
   
   PMID: 8723489, UI: 96300560
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   J Infect 1999 Jan;38(1):18-21
   
Elevated non-transferrin bound iron in the lungs of patients with Pneumocystis
carinii pneumonia.

    Mateos F, Gonzalez C, Dominguez C, Losa JE, Jimenez A, Perez-Arellano JL
    
   Departamento de Medicina, Facultad de Medicina, Universidad de
   Salamanca.
   
   OBJECTIVE: The aim of the present work was to determine the
   concentrations of iron and iron-binding proteins in the lungs of
   patients suffering from Pneumocystis carinii (PCP), which is crucial
   for justifying the treatment with iron-chelating agents in this
   disease. PATIENTS AND METHODS: Bronchoalveolar lavage was performed in
   10 HIV patients with PCP and five healthy controls. Total iron and
   iron-binding proteins (transferrin, ferritin and lactoferrin) were
   measured in acellular bronchoalveolar lavage fluid (BALF) in both
   groups. Iron was determined by atomic absorption spectrometry;
   transferrin and lactoferrin were measured using specific enzyme-linked
   immunosorbent assays (ELISA); and ferritin concentration was
   quantified by automated immunonephelometry. RESULTS: Our findings in
   patients with PCP demonstrated a six- to seven-fold increase of total
   iron levels and an eight-fold increase of ferritin in bronchoalveolar
   lavage fluid when compared with controls. No significant differences
   were found in transferrin or lactoferrin levels. Moreover, our results
   suggest that this iron is non-transferrin bound. CONCLUSION:
   Non-transferrin bound iron is increased in the lower respiratory
   tracts of PCP patients. This finding would lend experiment support to
   the use of iron-chelating agents in this disease.
   
   PMID: 10090500, UI: 99188909
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   Save the above report in [Macintosh] [Text] format
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   J Infect 1999 Jan;38(1):18-21
   
Elevated non-transferrin bound iron in the lungs of patients with Pneumocystis
carinii pneumonia.

    Mateos F, Gonzalez C, Dominguez C, Losa JE, Jimenez A, Perez-Arellano JL
    
   Departamento de Medicina, Facultad de Medicina, Universidad de
   Salamanca.
   
   OBJECTIVE: The aim of the present work was to determine the
   concentrations of iron and iron-binding proteins in the lungs of
   patients suffering from Pneumocystis carinii (PCP), which is crucial
   for justifying the treatment with iron-chelating agents in this
   disease. PATIENTS AND METHODS: Bronchoalveolar lavage was performed in
   10 HIV patients with PCP and five healthy controls. Total iron and
   iron-binding proteins (transferrin, ferritin and lactoferrin) were
   measured in acellular bronchoalveolar lavage fluid (BALF) in both
   groups. Iron was determined by atomic absorption spectrometry;
   transferrin and lactoferrin were measured using specific enzyme-linked
   immunosorbent assays (ELISA); and ferritin concentration was
   quantified by automated immunonephelometry. RESULTS: Our findings in
   patients with PCP demonstrated a six- to seven-fold increase of total
   iron levels and an eight-fold increase of ferritin in bronchoalveolar
   lavage fluid when compared with controls. No significant differences
   were found in transferrin or lactoferrin levels. Moreover, our results
   suggest that this iron is non-transferrin bound. CONCLUSION:
   Non-transferrin bound iron is increased in the lower respiratory
   tracts of PCP patients. This finding would lend experiment support to
   the use of iron-chelating agents in this disease.
   
   PMID: 10090500, UI: 99188909
     _________________________________________________________________
   
   Save the above report in [Macintosh] [Text] format
   Order documents on this page through Loansome Doc
     _________________________________________________________________