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Subject:palsy

 
   
  
   Am J Pathol 1998 Jun;152(6):1531-9
   
Ferritin is associated with the aberrant tau filaments present in progressive
supranuclear palsy.

    Perez M, Valpuesta JM, de Garcini EM, Quintana C, Arrasate M, Lopez
    Carrascosa JL, Rabano A, Garcia de Yebenes J, Avila J
    
   Centro de Biologia Molecular Severo Ochoa Universidad Autonoma de
   Madrid, Spain.
   
   Tau-containing filaments purified from the brain of progressive
   supranuclear palsy (PSP) patients were isolated and characterized.
   These filaments co-purify with regular particles that biophysical and
   biochemical methods identified as ferritin shells. In vivo, brain tau
   accumulation in PSP co-localized with ferritin. These results suggest
   that ferritin/iron could modulate the formation of tau aggregates in
   PSP.
   
   PMID: 9626057, UI: 98289297
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