(HOME) Subject: SSCN/siderosis/hearing


   Vol. 62, No. 5, 2000
   
   Case Report
   Superficial Siderosis of the Central Nervous System
   A Case Report on Examination by ECoG and DPOAE
   Kenji Takasaki, Fujinobu Tanaka, Koichiro Shigeno, Yukihiko Kanda,
   Ippei Kawajiri, Tetsuya Tashiro, Toshimitsu Kobayashi
   Department of Otolaryngology, Nagasaki University School of Medicine,
   Nagasaki, Japan
   ORL 62:5:2000, 270-273.
   Abstract
   
   This is a case of superficial siderosis of the central nervous system
   (SSCN). The diagnosis of SSCN was based on the result of T2-weighted
   magnetic resonance imaging and on suggestive clinical manifestations.
   The pure-tone audiogram showed bilateral progressive sensorineural
   hearing loss with a poor speech discrimination score and Jerger type
   IV. The remarkable elevation of the detective threshold of cochlear
   microphonics on electrocochleography was found and distortion product
   otoacoustic emission (DPOAE) showed no response: These
   electrophysiologic examinations, including electrocochleography and
   DPOAE, revealed that the progressive sensorineural hearing loss in
   this case was caused by both retrocochlear and cochlear damages.
   


Subject: SSCN/siderosis/hearing


   Vol. 43, No. 2, 2000
   
   Short Reports
   Superficial Siderosis of the Central Nervous System in a Patient with
   Neurofibromatosis Type I
   Michela Manfredia, Laura De Tognib, Alberto Beltramelloc
   aDipartimento di Neuroscienze, UF Neurologia, Poliambulanza, Brescia,
   bDipartimento di Neurologia, Clinica Pederzoli, Peschiera, Verona, and
   cServizio di Neuroradiologia, Ospedale Civile Maggiore, Verona, Italy
   European Neurology 43:2:2000, 121-122.
   Abstract
   
   Sorry, there is no abstract. Read the first few lines of the text
   instead!
   
   A patient aged 56 years was admitted for a long-standing history of
   headache associated with bilateral hearing loss. Physical examination
   disclosed multiple disseminated subcutaneous lesions (neurofibromas)
   associated with several 'café au lait' skin spots greater than 15 mm.
   The right orbital cavity was enlarged; the right ocular globe was
   hypoplastic, with enophthalmos alternating with pulsatile
   exophthalmos. Marked kyphoscoliosis of the cervicothoracic spine was
   evident. Neurological examination revealed mild gait ataxia and
   bilateral sensorineural hearing loss associated with impaired
   movements of the right eye.



   
   J Otolaryngol 1996 Feb;25(1):41-3
   
Superficial siderosis--a cause of audiovestibular failure.

    Longridge NS, Hashimoto S, Marotta TR, Mezei M
    
   Division of Otolaryngology, University of British Columbia, Faculty of
   Medicine.
   
   Bilateral vestibular end organ failure in adult life is a rare
   condition with some specific known causes, such as relapsing
   polychondritis, autoimmune inner ear disease, Lues venerium, and an
   acute effect of gentamicin. This case report draws attention to a rare
   condition that is potentially recognizable early in its development.
   The patient has superficial siderosis, which is iron deposits over the
   cerebrum, resulting in progressive neurologic failure involving all of
   the systems. Early in its course before other symptoms appear, there
   is development of progressive hearing loss and vestibular failure.
   This case report and literature review are given, including a
   potential for attempts at therapy if the disorder is recognized early.
   
   PMID: 8816109, UI: 96412863
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Subject: aminoglycoside/antibiotic

   
   DESCRIPTION
   
   PEDIATRIC GENTAMICIN SULFATE INJECTION, USP 
   
   10 mg/ml (gentamicin sulfate, USP equivalent to 10 mg gentamicin base)
   
   WARNINGS
   
    Patients treated with aminoglycosides should be under close clinical
    observation because of the potential toxicity associated wi th their
                                    use.
                                      
       Evidence of ototoxicity (dizziness,
         vertigo, tinnitus, roaring in the ears or hearing loss) or
     nephrotoxicity requires dosage adjustment or discontinuance of the
   drug. 

Subject: antibiotic/iron/adriamycin

   
   FEBS Lett 1986 Feb 17;196(2):321-4
   
Binding of transferrin-iron by adriamycin at acidic pH.

    Demant EJ, Norskov-Lauritsen N
    
   It is shown that adriamycin is able to chelate iron released from
   iron-loaded serum transferrin in the pH range from 6.5-4.1. The
   kinetics of iron transfer to free adriamycin and to adriamycin
   covalently attached to the transferrin has been determined. The
   results show that adriamycin, if introduced into intracellular acidic
   compartments, could function as acceptor for transferrin-iron.
   
   PMID: 3949004, UI: 86136541
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