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Subject: Iron/depletes antioxidants 


   Biochem. J. 300: 799-803 (1994)[94280407]

The effect of iron overload on rat plasma and liver oxidant status in vivo.



    A. J. Dabbagh, T. Mannion, S. M. Lynch & B. Frei



   Department of Nutrition, Harvard School of Public Health, Boston, MA
   02115.

   IO led to a significant decrease in
   the concentration of the antioxidants alpha-tocopherol and ascorbic
   acid in plasma, and alpha-tocopherol, beta-carotene and ubiquinol-10
   in liver. The data demonstrate that IO
   causes lipid metabolism disturbances and oxidative stress which is
   associated with substantial depletion of endogenous antioxidants and
   moderate lipid peroxidative damage.
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Subject: antioxidants and hemochromatosis


   Title: Antioxidant status and lipid peroxidation in hereditary
   haemochromatosis.

   Author(s): Young IS; Trouton TG; Torney JJ; McMaster D; Callender ME;
   Trimble ER

   Address: Department of Clinical Biochemistry, Queen's University of
   Belfast, UK.

   Source: Free Radic Biol Med 1994 Mar;16(3):393-7

   Abstract: Hereditary haemochromatosis is characterised by iron
   overload that may lead to tissue damage. Free iron is a potent
   promoter of hydroxyl radical formation that can cause increased lipid
   peroxidation and depletion of chain-breaking antioxidants.
   There were decreased levels
   of the chain-breaking antioxidants alpha-tocopherol , ascorbate
   and retinol Patients with
   hereditary haemochromatosis have reduced levels of antioxidant
   vitamins, and nutritional antioxidant supplementation may represent a
   novel approach to preventing tissue damage. However, the use of
   vitamin C may be deleterious in this setting as ascorbate can have
   prooxidant effects in the presence of iron overload
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