(HOME) 
Subject: iron/schizophrenia/chorea

   
   Schizophr Res 1995 Jul;16(1):73-6
   
Sydenham's chorea and schizophrenia: a case report.

    Casanova MF, Crapanzano KA, Mannheim G, Kruesi M
    
   Medical College of Georgia, Augusta 30910, USA.
   
   The following is a case report of a patient with Sydenham's chorea who
   later developed schizophrenia. Autopsy examination of this patient
   revealed mineral deposits in the basal ganglia. The deposition of
   minerals, especially iron, within subcortical brain structures has
   been associated with dopaminergic abnormalities, schizophreniform
   symptoms, and abnormal movement disorders. The psychosis these
   patients experience is sometimes resistant to treatment with
   traditional neuroleptics. A CT or MRI scan may prove useful in
   screening those patients with Sydenham's chorea that develop psychotic
   symptoms.
   
   PMID: 7547648, UI: 96015587
      (HOME) ____________________________________________________________    _________________________________________________________________



Subject: iron/chorea/schizophrenia

   
   Eur Neurol 1999;42(3):157-62
   
A case of hereditary ceruloplasmin deficiency with iron deposition in the brain
associated with chorea, dementia, diabetes mellitus and retinal pigmentation:
administration of fresh-frozen human plasma.

    Yonekawa M, Okabe T, Asamoto Y, Ohta M
    
   Department of Neurology, Hiroshima Kosei Hospital, Hiroshima, Japan.
   
   We report a familial case of hereditary ceruloplasmin deficiency (HCD)
   showing an A-G transition in intron 6 of the ceruloplasmin gene.
   Clinical features consisted of chorea, cerebellar ataxia, dementia,
   diabetes mellitus, retinal pigmentation and iron deposition in the
   liver and brain without copper overload in those organs. The patient's
   children and siblings had similar laboratory results, but did not show
   any neurological abnormalities. She was medicated for diabetes
   mellitus at 43 years of age, and neurological signs appeared when she
   was 52 years old. The laboratory findings were anemia, low
   concentrations of iron and copper in serum and of copper in urine.
   Ceruloplasmin was not detected in the serum. The iron and copper
   contents in the liver were 3,580 and 10 microg/g wet tissue,
   respectively. MRI of the brain showed iron deposition in the basal
   ganglia, dentate nucleus and thalamus. This case did not show any
   abnormal increase in copper in the blood and urine following
   CuSO(4)5H(2)O oral overloading test. Following the intravenous
   administration of commercially available fresh-frozen human plasma
   (FFP) containing ceruloplasmin, the serum iron content increased for
   several hours due to ferroxidase activity of ceruloplasmin. In the
   liver, the iron content decreased more with the combined intravenous
   administration of FFP and deferoxamine than with FFP administration
   alone. Her neurological symptoms improved following repetitive FFP
   treatment.
   
   Publication Types:
     * Review
     * Review of reported cases
       
   PMID: 10529542, UI: 20002496
     _ (HOME) ___________________________________________________________