(HOME) Subject: athletes foot/lactoferrin

   
   Mycoses 2000;43(5):197-202
   
Oral administration of bovine lactoferrin for treatment of tinea pedis. A
placebo-controlled, double-blind study.

    Yamauchi K, Hiruma M, Yamazaki N, Wakabayashi H, Kuwata H, Teraguchi S,
    Hayasawa H, Suegara N, Yamaguchi H
    
   Nutritional Science Laboratory, Morinaga Milk Industry Co., Ltd,
   Kanagawa, Japan.
   
   [Medline record in process]
   
   A clinical study was conducted to evaluate the effectiveness of
   lactoferrin, which is a protein component of cow's milk, in the
   treatment of tinea pedis. Doses of either 600 mg or 2000 mg of
   lactoferrin, or a placebo was orally administered daily for 8 weeks to
   37 adults who were judged to have mild or moderate tinea pedis.
   Dermatological improvement and antifungal efficacy were assessed. In
   the analysis of all subjects, dermatological symptoms scores in all
   groups decreased but the differences were not statistically
   significant comparing the three groups. However, in the analysis
   limited to subjects with moderate vesicular or interdigital tinea
   pedis, dermatological symptoms scores in the lactoferrin-treated
   groups decreased significantly in comparison with the placebo group (P
   < 0.05). The organisms isolated were Trichophyton rubrum and
   Trichophyton mentagrophytes. A mycological cure was not seen in any of
   the subjects. In the 37 subjects there were no adverse events and no
   subject withdrew from the study because of an adverse event. These
   results suggest that orally administered lactoferrin can improve the
   dermatological symptoms in some subjects. The potential usefulness of
   lactoferrin as a functional food material for treating tinea pedis was
   seen for the first time in this study.
   
   PMID: 10948819, UI: 20404620
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