(HOME) Subject: asthma/oxidation/antioxidants
J Am Coll Nutr 1995 Aug;14(4):317-24
Asthma and oxidant stress: nutritional, environmental, and genetic risk
factors.
Greene LS
Department of Anthropology, University of Massachusetts/Boston
02125-3393, USA.
A considerable body of evidence suggests that oxidant stress results
in inflammation and tissue damage in the respiratory system, and later
in immune damage, and that individuals with lowered cellular reducing
capacity are at increased risk to develop asthma. Reducing capacity in
the erythrocyte is generated through the pentose phosphate pathway and
this pathway also generates a major portion of the reducing capacity
in all cells of the body. Therefore, dietary, environmental, and
genetic factors which diminish cellular reducing capacity will
increase tissue vulnerability to oxidant stress and are likely to
increase asthma risk. Dietary selenium deficiency lowers red cell
glutathione peroxidase activity and is associated with an increased
risk for asthma, and low dietary intakes of vitamins C and E also
appear to increase asthma risk. High body iron stores increase free
radical production and may also elevate asthma risk. Environmental
lead exposure depresses the activities of a several enzyme systems
that influence cellular reducing capacity (glucose-6-phosphate
dehydrogenase, NAD synthetase, glutathione peroxidase, superoxide
dismutase, catalase) and consequently may increase asthma risk.
Genetically-determined low activity of glucose-6-phosphate
dehydrogenase lowers cellular reducing capacity and may also heighten
asthma risk. Simple dietary and environmental interventions may
significantly reduce oxidant stress and prevent or minimize the
development of asthmatic symptoms and should prove to be a cost
effective approach to asthma management in addition to current
pharmacological strategies.
Publication Types:
* Review
* Review, tutorial
PMID: 8568107, UI: 96025398
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Subject: ameboflagellate/asthma
Acta Cytol 1998 May-Jun;42(3):685-90
Ameboflagellates in bronchial asthma.
Ribas A, Mosquera JA
Anatomic Pathology Service, General Hospital of Asturias, Oviedo,
Spain.
OBJECTIVE: To distinguish between the existence of detached ciliary
tufts (DCTs) and the possibility of protozoa in the sputum of asthma
patients. STUDY DESIGN: One hundred six samples of sputum obtained
from 97 patients hospitalized with either asthma or other respiratory
diseases were examined blindly. The combination of such criteria as
movement, absence of basal plate, existence of red granules,
positivity for ultraviolet light and Heidenhain's iron hematoxylin
stain (for protozoa) was employed to distinguish between DCTs and true
protozoa. RESULTS: The presence of ameboflagellates in sputum has a
diagnostic accuracy of 86% in predicting or ruling. out the
possibility of acute asthma. CONCLUSION: The presence of
ameboflagellate forms is closely related to the existence of bronchial
asthma, and these result reflect some etiopathogenic significance in
asthma.
PMID: 9622688, UI: 98285891
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Subject: ameboflagellate
Appl Environ Microbiol 1983 Feb;45(2):665-8
Inhibition of Naegleria fowleri by microbial iron-chelating agents: ecological
implications.
Newsome AL, Wilhelm WE
Deferrioxamine B and rhodotorulic acid, iron-chelating agents of
microbial origin, exerted a pronounced inhibitory effect on pathogenic
Naegleria fowleri at microgram levels. This inhibition was diminished
by adding iron to the chelators before incubation with Naegleria
isolates. These and related microbial iron chelators occur naturally
in the environment. This could be of considerable ecological
significance and provides a novel hypothesis to account for the
proliferation of pathogenic Naegleria spp. in certain aquatic
habitats.
PMID: 6830222, UI: 83151514
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Subject: ameboflagellate/ph/acidosis
Experientia 1981 Nov 15;37(11):1160-2
Effect of exogenous iron on the viability of pathogenic Naegleria fowleri in
serum.
Newsome AL, Wilhelm WE
When Naegleria fowleri (Lee) was incubated in newborn calf and human
serum an amebicidal effect was observed. Heat inactivation of both
sera resulted in the recovery of viable amebae after incubation in
these sera. Exogenous iron added to non-heat inactivated calf serum
improved viability slightly but was without effect when added to human
serum not heat inactivated. Exogenous iron greatly enhanced growth
and/or viability in heat inactivated calf serum. Viability of amebae
also was considerably enhanced in human serum which was heat
inactivated when pH was lowered in conjunction with iron supplements.
PMID: 7318996, UI: 82095502
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Subject: asthma/ph/acidosis
With progressive severity and duration of the episode, respiratory
acidosis may supervene; the arterial pH may drop alarmingly to ranges
of pH 7 to 7.1. Most adults are intubated at this stage and started on
assisted ventilation, because the acidosis mainly reflects a
respiratory mechanical problem that must be relieved. Use of alkaline
solutions (eg, sodium bicarbonate) in the IV fluid should be limited
to maintain the pH between 7.2 and 7.3, since there is some evidence
that adrenergic agent resistance is reversed by normalizing the pH.
While there are theoretic objections to adding bicarbonate to a closed
system, sodium bicarbonate has been safely and successfully used in
children and adults with status asthmaticus. It should be used only
with careful ABG and pH monitoring.
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Subject: asthma
This is an excerpt from a post from a person being treated for iron
excess/overload.
Beneficial Effect
I don't know if it is a coincidence, but after several phlebs, my asthma
and allergy symptoms became better and have nearly cleared up.
I was taking proventil, intal, vancenase, theophylline and
beclovent daily. I no longer take theophylline, proventil and have cut
back on the rest 90%. I have not had an attack, can smell food, do not have
cotton mouth during the night for the first time in years and my wife says
that I NO LONGER SNORE. It's probably a coincidence, but I like to think of
it as a possible positive side affect.
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