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 Subject: acne/ROS/oxidation

   Vol. 196, No. 1, 1998
   
   Paper
   The Possible Role of Reactive Oxygen Species Generated by Neutrophils
   in Mediating Acne Inflammation
   H. Akamatsu, T. Horio
   Department of Dermatology, Kansai Medical University, Osaka, Japan
   Dermatology 196:1:1998, 82-85.
   Abstract
   
   The purpose of this study was to investigate the possible role of
   reactive oxygen species (ROS) generated by neutrophils in mediating
   acne inflammation. Antibiotics used for the treatment of acne
   significantly inhibited ROS generated by neutrophils, when compared to
   other antibiotics. Metronidazole, which is effective in the treatment
   of acne, markedly inhibited ROS generated by neutrophils. The drug is
   known to have no significant effect on the growth of Propionibacterium
   acnes. The proportion of linoleic acid is markedly decreased in acne
   comedones. Linoleic acid significantly suppressed ROS generated by
   neutrophils. The ability of neutrophils to produce ROS was
   significantly increased in patients with acne inflammation. These
   results seem to reveal the involvement of ROS generated by neutrophils
   in the disruption of the integrity of the follicular epithelium, which
   is responsible for inflammatory processes of acne.


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